Adderall vs. Vyvanse Similarities and Differences: Choose What’s Right For You
Adderall and Vyvanse are two of the more common medications prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Both are Schedule II controlled substances as both are central nervous system (CNS) stimulants with a significant potential for misuse and dependence. [1] Both medications are the first-line option for treating ADHD and the symptoms associated with that disorder.

Frequently Asked Questions About Adderall and Vyvanse
Will Vyvanse give you energy?
Any central nervous system stimulant (CNS) medication can elevate your energy, focus, alertness, and wakefulness. How your body reacts to Vyvanse depends on your biological makeup, medical history, drug interactions, and other factors.
What Is Adderall XR?
Adderall XR is the brand name for Adderall Extended Release and has a once-daily dose of 20mg for ADHD.[16] This is most common for those switching to Adderall from another medication.
What is better, Vyvanse or Adderall?
Medication choice is too personalized to answer here. What works for you may not be suitable for someone else. Dosing, administration, use, and frequency may vary from person to person and should only be assigned by a physician.
Who shouldn’t take Adderall or Vyvanse?
Both medications share a spectrum of conditions that may eliminate some from taking either one, including substance abuse history, cardiovascular issues, serious psychological issues, or circulation issues. [17][18]
Which drug is best for ADHD?
Both Adderall and Vyvanse are approved as first-line treatments for attention-deficit hyperactivity disorder (ADHD). Adderall is available in immediate-release (IR) formulas and extended-release (XR), while Vyvanse is only a once-daily, extended-release-like solution.
Are there other non-stimulant drugs for ADHD?
Yes, there are some non-stimulant options for treating ADHD, but they may have varying effectiveness. These are suitable for those who can’t or don’t wish to take stimulants, either due to biological tolerance or substance abuse history. Some medication options include: [19]
- Atomoxetine
- Clonidine
- Guanfacine
[1]Drug scheduling. DEA. (n.d.-a). https://www.dea.gov/drug-information/drug-scheduling
[2][3]U.S. Department of Health and Human Services. (n.d.-a). Attention-deficit/hyperactivity disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/attention-deficit-hyperactivity-disorder-adhd
[4][5]Martin, D. (2023, July 31). Amphetamine. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK556103/
[6][9][11][13][16][17]Adderall: Uses, dosage, Side Effects & Safety Info. Drugs.com. (n.d.-c). https://www.drugs.com/adderall.html
[7][10][12][18]Vyvanse uses, dosage, side effects & warnings. Drugs.com. (n.d.-k). https://www.drugs.com/vyvanse.html
[8]Vankar, P. (2024, January 24). Adderall use annual prevalence among U.S. students 2022. Statista. https://www.statista.com/statistics/696590/us-annual-prevalence-of-adderall-use-in-grades-8-10-12-since-2009/
[14]Efficacy of adderall® for attention-deficit/hyperactivity disorder: … (n.d.-b). https://journals.sagepub.com/doi/10.1177/108705470200600203
[15]Goodman, D. W. (2010, May). Lisdexamfetamine dimesylate (vyvanse), a prodrug stimulant for attention-deficit/hyperactivity disorder. P & T : a peer-reviewed journal for formulary management. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873712/
[19]U.S. National Library of Medicine. (n.d.-c). What medications are used to treat ADHD? | NIH MedlinePlus Magazine. MedlinePlus. https://magazine.medlineplus.gov/article/what-medications-are-used-to-treat-adhd