Medical Reviewer

Adderall vs. Vyvanse Similarities and Differences: Choose What’s Right For You

Last Medical Review On: April 7, 2025
Updated On: April 7, 2025
4 min read
Written by:

Amanda Stevens, B.S.

Medical Review by:

Dr. Po-Chang Hsu, M.D., M.S.

Adderall and Vyvanse are two of the more common medications prescribed for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Both are Schedule II controlled substances as both are central nervous system (CNS) stimulants with a significant potential for misuse and dependence. [1] Both medications are the first-line option for treating ADHD and the symptoms associated with that disorder.

Adderall vs. Vyvanse: Varieties of pill capsules. Some solid blue, some light blue, some split blue and white, and some red.

Key Points

  • Adderall and Vyvanse are both stimulant medications used to treat ADHD, though they contain different formulations of amphetamine.
  • Both medications are Schedule II controlled substances that carry a significant risk of abuse and dependence.
  • As stimulants, these medications for ADHD primarily increase the levels of dopamine and norepinephrine in the brain, which helps regulate attention, impulsivity, and hyperactivity symptoms associated with ADHD.
  • Adderall and Vyvanse have similar uses, side effects, risks, and warnings.
  • These two medications differ in dosage, formula, how they’re taken, and the age when they can be prescribed.
  • Both medications are approved as a first-line treatment for ADHD, offering significant symptom management and relief for children and adults.
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    Living With ADHD: Signs and Symptoms

    Attention deficit hyperactivity disorder is a disruptive mental health disorder commonly diagnosed in childhood but is still prevalent in adults. ADHD interferes with routine functioning and can impact development. Someone with ADHD may present symptoms including:[2]

    • Inattentive: They may be easily distracted, struggle to follow through, start tasks they can’t finish, or have trouble managing time. This can result in unfinished projects, forgetting things, missing deadlines, mistakes, and being easily sidetracked.
    • Hyperactive: They may feel chronically restless and unable to stay still, constantly fidgeting. Many also struggle with antisocial behavior and difficulty maintaining relationships.
    • Impulsivity and Poor Self-Control: Individuals may struggle with delayed gratification, frequently make impulsive decisions, and have difficulty with active listening, often interrupting others during conversations.

    Who is more at risk for ADHD?

    There is no definitive cause of ADHD, but medical and mental health professionals consider the following components to influence ADHD:[3]

    • Genetics
    • Environmental factors
    • Brain injuries
    • Nutrition
    • Social environments

    If you believe you or a loved one may have ADHD, consult a healthcare professional. They will assess your symptoms and determine the best course of action for treatment.

    Why Stimulants Are Used To Treat ADHD

    Why Stimulants Are Used To Treat ADHD: Stimulants, such as the active ingredients in Adderall and Vyvanse, stimulate the central nervous system, increasing the levels of dopamine and norepinephrine.[4] This action helps to improve focus, attention, and control over impulsivity and hyperactivity in individuals with ADHD.  Those with ADHD struggle to stay focused and motivated, making stimulants the first-line treatment for this disorder.

    A Comparison of Adderall and Vyvanse

    Choosing the right medication is a decision that should be made with your doctor and will depend on your individual needs.

    Similarities of Adderall vs Vyvanse

    • Mechanism of Action (How it works in the brain and body): Stimulant medications like Adderall and Vyvanse increase the availability of neurotransmitters, specifically dopamine and norepinephrine, in the brain. This action enhances focus, motivation, and wakefulness in individuals with ADHD. [5]
    • Amphetamine Ingredients: Both of these two medications have a similar formula, both containing amphetamines. Adderall contains two active ingredients, amphetamine and dextroamphetamine, whereas Vyvanse contains one primary amphetamine ingredient, lisadexamfetamine.[6][7]
    • Side effects: Adderall and Vyvanse are associated with many of the same side effects, including heart issues, circulation problems, weight loss, sleep issues, rapid heart rate, and more.
    • Abuse potential: As Schedule II controlled substances, both Adderall and Vyvanse carry a significant risk of misuse and dependence. Adderall, in particular, has been noted for its high abuse potential among school-aged teenagers in the United States. [8]
    • Risks and Warnings: Both substances carry health warnings regarding cardiac issues, pregnancy concerns, high blood pressure, serotonin syndrome, stroke, and more.

    Differences of Adderall vs Vyvanse

    Differences of Adderall vs. Vyvanse

    • Usage: While both Adderall and Vyvanse are prescribed to treat attention deficit hyperactivity disorder (ADHD), Adderall is also used to treat narcolepsy.[9] Vyvanse is also prescribed to treat adults with moderate to severe binge eating disorder.[10]
    • Patient Age: Adderall is prescribed for children as young as 3, but Vyvanse is only suitable for children 6 and older.
    • Formulation: Adderall is available in immediate and extended-release prescriptions, but Vyvanse is only prescribed as an extended-release formula.
    • Administration: Vyvanse is available as a capsule that can be mixed with liquid and a chewable tablet.[11] Prescription Adderall is a tablet that must be swallowed and never crushed or chewed.[12]
    • Dosage: Vyvnase prescriptions will vary at the discretion of your physician and based on your need. The typical adult dosage for Adderall for ADHD is 5 or 10 mg per day.[13]

    Adderall vs. Vyvanse Effectiveness

    Individual responses to medication can vary, but research supports the effectiveness of both Adderall and Vyvanse in treating ADHD. Standard and extended-release formulations of Adderall have been shown to reduce symptoms such as inattention and hyperactivity. It reduced the symptoms of inattention, hyperactivity, impulsivity, and aggression across the board. [14] However, concerns remain for any patient regarding the high potential for misuse, especially with long-term use.

    This is where Vyvanse may be a more suitable alternative when compared to other extended-release stimulants for ADHD (like Adderall). Vyvanse is effective in doses of 30 to 70 mg per day and may have a lower potential for abuse.[15] This shows promise in reducing the risk of abuse.

    Both medications are approved as a first-line treatment for ADHD, indicating they offer significant symptom management and relief. Choosing the right medication for you will depend on several biological and medical history factors, including a history of substance misuse or other mental health concerns.

    Adderall vs. Vyvanse: Is one stronger than the other?

    The exact Vyvanse dosage will vary from patient to patient, so a direct potency comparison is difficult to determine. Adderall is available in an immediate-release formula, while Vyvanse acts as an extended-release only. This could influence the perception that Vyvanse is stronger than Adderall.

    Help For Substance Use or Co-Occurring Disorders

    Living with ADHD presents several challenges to productivity, function, and quality of life. When paired with a substance use disorder, these concerns can escalate into something more debilitating.

    We’re here to help. Reach out for support and direction. Let’s reset your path in life and build a bridge to a safer, happier tomorrow.

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    To ensure accuracy and quality, every contributor to the Alpas Wellness resource library undergoes a thorough evaluation of their experience, credentials, and achievements prior to publication.

    Frequently Asked Questions About Adderall and Vyvanse

    01

    Will Vyvanse give you energy?

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    Any central nervous system stimulant (CNS) medication can elevate your energy, focus, alertness, and wakefulness. How your body reacts to Vyvanse depends on your biological makeup, medical history, drug interactions, and other factors.

    01

    What Is Adderall XR?

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    Adderall XR is the brand name for Adderall Extended Release and has a once-daily dose of 20mg for ADHD.[16] This is most common for those switching to Adderall from another medication.

    01

    What is better, Vyvanse or Adderall?

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    Medication choice is too personalized to answer here. What works for you may not be suitable for someone else. Dosing, administration, use, and frequency may vary from person to person and should only be assigned by a physician.

    01

    Who shouldn’t take Adderall or Vyvanse?

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    Both medications share a spectrum of conditions that may eliminate some from taking either one, including substance abuse history, cardiovascular issues, serious psychological issues, or circulation issues. [17][18]

    01

    Which drug is best for ADHD?

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    Both Adderall and Vyvanse are approved as first-line treatments for attention-deficit hyperactivity disorder (ADHD). Adderall is available in immediate-release (IR) formulas and extended-release (XR), while Vyvanse is only a once-daily, extended-release-like solution.

    01

    Are there other non-stimulant drugs for ADHD?

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    Yes, there are some non-stimulant options for treating ADHD, but they may have varying effectiveness. These are suitable for those who can’t or don’t wish to take stimulants, either due to biological tolerance or substance abuse history. Some medication options include: [19]

    • Atomoxetine
    • Clonidine
    • Guanfacine
    Sources
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    [01]

    [1]Drug scheduling. DEA. (n.d.-a). https://www.dea.gov/drug-information/drug-scheduling

    [2][3]U.S. Department of Health and Human Services. (n.d.-a). Attention-deficit/hyperactivity disorder. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/attention-deficit-hyperactivity-disorder-adhd

    [4][5]Martin, D. (2023, July 31). Amphetamine. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK556103/

    [6][9][11][13][16][17]Adderall: Uses, dosage, Side Effects & Safety Info. Drugs.com. (n.d.-c). https://www.drugs.com/adderall.html

    [7][10][12][18]Vyvanse uses, dosage, side effects & warnings. Drugs.com. (n.d.-k). https://www.drugs.com/vyvanse.html

    [8]Vankar, P. (2024, January 24). Adderall use annual prevalence among U.S. students 2022. Statista. https://www.statista.com/statistics/696590/us-annual-prevalence-of-adderall-use-in-grades-8-10-12-since-2009/

    [14]Efficacy of adderall® for attention-deficit/hyperactivity disorder: … (n.d.-b). https://journals.sagepub.com/doi/10.1177/108705470200600203

    [15]Goodman, D. W. (2010, May). Lisdexamfetamine dimesylate (vyvanse), a prodrug stimulant for attention-deficit/hyperactivity disorder. P & T : a peer-reviewed journal for formulary management. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873712/

    [19]U.S. National Library of Medicine. (n.d.-c). What medications are used to treat ADHD? | NIH MedlinePlus Magazine. MedlinePlus. https://magazine.medlineplus.gov/article/what-medications-are-used-to-treat-adhd

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