Ambien Withdrawal Symptoms, Timeline and Treatment
Substance Use Disorder Resources and Treatment
Zolpidem, also known as Ambien, Ambien CR, Edluar, Intermezzo, and Zolpimist, is a medication that’s prescribed for insomnia. Ambien is a Schedule IV controlled substance because of its risk of abuse and dependence, however.[1]
People who use Ambien long-term can develop a tolerance for the drug, leading them to take more to get the same effects. Over time, this leads to Ambien addiction, and if you try to quit, you may experience unpleasant withdrawal symptoms.[2]
What Is Ambien Withdrawal Like?
Ambien Withdrawal Symptoms
Ambien influences gamma-aminobutyric acid (GABA), a primary inhibitory neurotransmitter for the central nervous system that reduces excitability by inhibiting nerve transmission.[3] With regular Ambien use, the brain and body become dependent on the drug to function properly, so stopping suddenly can bring on unpleasant withdrawal symptoms.
With low-dose Ambien, withdrawal typically includes trouble sleeping for several days. But with higher doses, especially misuse, withdrawal symptoms may include:
- Abdominal pain
- Anxiety
- Euphoria
- High blood pressure
- Confusion, delirium, or disorientation
- Irritability
- Trouble sleeping
- Speech problems
- Restlessness
- Seizures
- Tremors[4]
Ambien Withdrawal Timeline
Ambien has a half-life of about three hours. Typically, the symptoms of withdrawal with sedative medications like Ambien develop six to eight hours after the final dose. Withdrawal symptoms typically peak one to five days after the last dose and subside over a few weeks.
Withdrawal can be different for everyone, however. The length of use and dosage of Ambien significantly affect the intensity of withdrawal.[5] Older adults or people with co-occurring disorders may experience more severe withdrawal symptoms.
Post-Acute Withdrawal Syndrome for Ambien
Post-acute withdrawal syndrome (PAWS) is a set of symptoms that occur after quitting a drug of abuse. Also known as prolonged withdrawal syndrome or protracted withdrawal syndrome, PAWS has symptoms similar to mood disorders or anxiety disorders.
PAWS is most likely to occur after an acute withdrawal from alcohol, opioids, or benzodiazepines, but it can occur with other substances like Ambien. The symptoms of PAWS fluctuate in severity and may linger after withdrawal or disappear and reappear. These symptoms include:[6]
- Learning and memory problems
- Anxiety
- Depression
- Irritability
- Obsessive-compulsive behaviors
- Cravings for substances
- Pessimism or apathy
- Low tolerance for stress
- Sleep issues
Types of Drug Withdrawal Treatment
Experts recommend tapering off of Ambien to discontinue use – with or without addiction – to lessen the severity of withdrawal symptoms. Depending on the dosage, you may need to taper off Ambien following a specific plan to get your body used to progressively lower amounts of the drug.[7]
A common schedule for tapering plans would include a minimal deduction in the standard dosage each week. For example, the dosage could be reduced by 25% for a few weeks and gradually increase the reduction percentage over time.
This is done under the supervision of a physician, which is why detox can be helpful for Ambien withdrawal treatment. With round-the-clock medical care, Ambien tapering can be monitored, and any withdrawal symptoms can be addressed immediately.
If you’ve taken Ambien for long periods of time or at higher doses, it can be dangerous to go through withdrawal. You may develop serious symptoms like seizures or delirium.[8]
Detox is an important step in getting through Ambien withdrawal, but it’s not enough to manage the underlying addiction to the substance. Ongoing treatment is an important part of uncovering the thoughts, emotions, and behaviors that led to Ambien’s abuse and addiction.
Treatment is individualized but may include:
Behavioral Therapies
Behavioral therapies like cognitive behavioral therapy (CBT) can be highly effective at treating not only the Ambien addiction but insomnia that led to its use – and misuse.[9] One-on-one sessions are key to addiction treatment programs to address the underlying psychological issues that contribute to addiction and learn appropriate ways to manage behaviors and avoid relapse.
Medications Used for Ambien Withdrawal
Depending on the dose, Ambien and other sedative-hypnotic drugs can have mild to severe withdrawal symptoms, including a risk of seizures or delirium. In some cases, medical detox with benzodiazepines or other long-acting sedatives is necessary to mitigate the risk of complications.[11]
What’s the Best Way to Find Ambien Withdrawal Treatment?
Ambien withdrawal can last for weeks, so detox is often the first step in getting Ambien addiction treatment. If you or a loved one are struggling with Ambien addiction, you can speak with your physician or therapist to find a detox center. The Substance Abuse and Mental Health Services Administration (SAMHSA) also offers resources for detox centers near you.
If you’re ready to take the first step now, Alpas Wellness offers a 24/7 confidential helpline with compassionate professionals to assist you. Contact us today to learn more.
Find Ambien Withdrawal Treatment Near Me
Facilities that specialize in withdrawal treatment
Click on a pin to learn more information on a specific facility location
Cost of Drug Withdrawal Treatment
The cost of Ambien withdrawal treatment can vary according to the level of care and therapies you need. Fortunately, many health insurance providers cover substance use disorder treatment. Contact our team at Alpas Wellness to see if you have an in-network provider.
Frequently Asked Questions About Withdrawal Treatment
What Is Considered Long-Term Use of Ambien?
Ambien is typically prescribed for a few weeks, then the use and dosage are reevaluated.[12] For some people, sleep is still difficult without Ambien, and they may continue to take Ambien past that timeframe.[12] Taking Ambien for longer periods increases the risk of dependency and abuse, however.
Is It Bad to Take Ambien Every Night?
Ambien use should be monitored by your physician. Taking Ambien more frequently, at higher doses, or for longer than prescribed can increase the risk of dependence, addiction, overdose, or other complications.
Does Ambien Stop Working?
For some people, Ambien stops working as tolerance occurs.[13] This is another reason that Ambien is recommended as a short-term (as short as possible) solution for insomnia.
Additional Resources
Also see these additional resources on withdrawal timelines and treatment:
Controlled substances – alpha order – dea diversion control division. (n.d.-a). Retrieved from https://deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf on 2023. July 2.
Heydari, M., & Isfeedvajani, M. S. (2013, November). Zolpidem dependence, abuse and withdrawal: A case report. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906775/ on 2023, July 2.
GABA receptor – statpearls – NCBI bookshelf. (n.d.-b). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK526124/ on 2023, July 2.
Heydari, M., & Isfeedvajani, M. S. (2013, November). Zolpidem dependence, abuse and withdrawal: A case report. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906775/ on 2023, July 2.
Weaver, M. F. (2015, September 3). Prescription sedative misuse and abuse. The Yale journal of biology and medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553644/ on 2023, July 2.
Post-acute withdrawal syndrome (PAWS). Post-Acute Withdrawal Syndrome (PAWS) | Semel Institute for Neuroscience and Human Behavior. (n.d.-a). Retrieved from https://www.semel.ucla.edu/dual-diagnosis-program/News_and_Resources/PAWS on 2023, July 2.
Zolpidem monograph for professionals. Drugs.com. (n.d.). Retrieved from https://www.drugs.com/monograph/zolpidem.html on 2023, July 2.
Mattoo, S. K., Gaur, N., & Das, P. P. (2011, November). Zolpidem withdrawal delirium. Indian journal of pharmacology. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229797/ on 2023, July 2.
Mayo Foundation for Medical Education and Research. (2023, April 5). Insomnia treatment: Cognitive behavioral therapy instead of Sleeping Pills. Mayo Clinic. Retrieved from https://www.mayoclinic.org/diseases-conditions/insomnia/in-depth/insomnia-treatment/art-20046677 on 2023, July 2.
Insomnia. NHS inform. (n.d.). Retrieved from https://www.nhsinform.scot/illnesses-and-conditions/mental-health/insomnia on 2023, July 2.
A treatment improvement protocol tip 45 (n.d.-a). Retrieved from https://store.samhsa.gov/sites/default/files/d7/priv/sma15-4131.pdf on 2023, July 2.
Zolpidem monograph for professionals. Drugs.com. (n.d.). Retrieved from https://www.drugs.com/monograph/zolpidem.html on 2023, July 2.
Göder R;Treskov V;Burmester J;Aldenhoff JB;Hinze-Selch D; (n.d.). [zolpidem: The risk of tolerance and dependence according to case reports, systematic studies and recent molecularbiological data]. Fortschritte der Neurologie-Psychiatrie. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11753748/ on 2023, July 2.
