Cocaine Withdrawal Timeline, Treatments, and Symptoms
Cocaine is a powerful stimulant drug that’s derived from the naturally occurring coca plant native to South America.
The raw plant has been used for medicinal purposes for millennia, but the pure chemical form – cocaine hydrochloride – was isolated over a century ago for use in tonics and elixirs.[1]
With the developments in medicine over the last century, cocaine fell out of favor for medicinal use and is now a drug of abuse. When snorted, injected, or smoked in its crystal form (crack), cocaine produces an intense high that often leads to misuse, dependency, and subsequent withdrawal.[2]

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Why Does Stopping Cocaine Cause Withdrawal?
Cocaine is a potent stimulant that produces intense euphoria by causing the brain to release abnormally high amounts of dopamine and other neurotransmitters.[14] This creates a sense of pleasure reinforced in the brain’s reward center, leading to continued use and eventual dependency. Then, when the brain and body are deprived of cocaine and can no longer function normally, withdrawal happens.
Cocaine is also known for its high risk of dependency, meaning people are more likely to become dependent on cocaine after initial experimentation than with many other drugs.
What Are the Risks of Cocaine Withdrawal?
Cocaine withdrawal doesn’t have life-threatening complications like some other substances. For example, quitting alcohol “cold turkey” can cause seizures or delirium tremens that can be deadly.
Still, cocaine withdrawal does carry risks. Some people experience severe dysphoria that can lead to suicidal thoughts or actions, including completed suicide.[15] The intense withdrawal symptoms and cravings can cause relapse, which may result in an overdose.
Cocaine | National Institute on Drug Abuse. (2024, April 4). National Institute on Drug Abuse. Retrieved from https://nida.nih.gov/research-topics/cocaine on 2024, June 18
Cocaine | National Institute on Drug Abuse. (2024, April 4). National Institute on Drug Abuse. Retrieved from https://nida.nih.gov/research-topics/cocaine on 2024, June 18
Substance Abuse and Mental Health Services Administration. (n.d.). A Treatment Improvement Protocol TIP 45. Retrieved from https://store.samhsa.gov/sites/default/files/d7/priv/sma15-4131.pdf on 2023, June 29.
Substance Abuse and Mental Health Services Administration. (n.d.). A Treatment Improvement Protocol TIP 45. Retrieved from https://store.samhsa.gov/sites/default/files/d7/priv/sma15-4131.pdf on 2023, June 29.
Substance Abuse and Mental Health Services Administration. (n.d.). A Treatment Improvement Protocol TIP 45. Retrieved from https://store.samhsa.gov/sites/default/files/d7/priv/sma15-4131.pdf on 2023, June 29.
Ferguson, S. (2022, October 19). How to Recognize and Manage the Symptoms of Post-Acute Withdrawal Syndrome. Healthline. Retrieved from https://www.healthline.com/health/post-acute-withdrawal-symptoms on 2024, June 6.
Ferguson, S. (2022, October 19). How to Recognize and Manage the Symptoms of Post-Acute Withdrawal Syndrome. Healthline. Retrieved from https://www.healthline.com/health/post-acute-withdrawal-symptoms on 2024, June 6.
Cocaine | National Institute on Drug Abuse. (2024, April 4). National Institute on Drug Abuse. Retrieved from https://nida.nih.gov/research-topics/cocaine#treated on 2024, June 12.
Cocaine | National Institute on Drug Abuse. (2024, April 4). National Institute on Drug Abuse. Retrieved from https://nida.nih.gov/research-topics/cocaine#treated on 2024, June 12.
Cocaine | National Institute on Drug Abuse. (2024, April 4). National Institute on Drug Abuse. Retrieved from https://nida.nih.gov/research-topics/cocaine#treated on 2024, June 12.
Nestler, E. (2005). The Neurobiology of cocaine Addiction. Science & Practice Perspectives, 3(1), 4–10. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851032/ on 2024, August 16th.
Havlicek, D. F., Rosenberg, J. B., De, B. P., Hicks, M. J., Sondhi, D., Kaminsky, S. M., & Crystal, R. G. (2020). Cocaine vaccine dAd5GNE protects against moderate daily and high-dose “binge” cocaine use. PloS One, 15(11), e0239780. Retrieved from https://doi.org/10.1371/journal.pone.0239780 on 2024, June 12.
Kampman, K. (2008). The search for medications to treat stimulant dependence. Addiction Science & Clinical Practice, 4(2), 28–35. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797110/ on 2024, August 16th.
Venton, B. J., Seipel, A. T., Phillips, P. E. M., Wetsel, W. C., Gitler, D., Greengard, P., Augustine, G. J., & Wightman, R. M. (2006). Cocaine increases dopamine release by mobilization of a Synapsin-Dependent reserve pool. the Journal of Neuroscience/the Journal of Neuroscience, 26(12), 3206–3209. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674099/ on 2024, June 12.
Substance Abuse and Mental Health Services Administration. (n.d.). A Treatment Improvement Protocol TIP 45. Retrieved from https://store.samhsa.gov/sites/default/files/d7/priv/sma15-4131.pdf on 2023, June 29.