Ambien Withdrawal Symptoms, Timeline and Treatment
Zolpidem, also known as Ambien, Ambien CR, Edluar, Intermezzo, and Zolpimist, is a medication that’s prescribed for insomnia. Ambien is a Schedule IV controlled substance because of the risk of abuse and dependence.[1]
People who use Ambien long-term can develop a tolerance for the drug, leading them to take more to get the same effects. Over time, this leads to Ambien addiction, and if you try to quit, you may experience unpleasant withdrawal symptoms.[2]

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Frequently Asked Questions About Withdrawal Treatment
What Is Considered Long-Term Use of Ambien?
Ambien is typically prescribed for a few weeks, then the use and dosage are reevaluated. For some people, sleep is still difficult without Ambien, and they may continue to take Ambien past that timeframe.[13] Taking Ambien for longer periods increases the risk of dependency and abuse, however.
Is It Bad to Take Ambien Every Night?
Ambien use should be monitored by your physician. Taking Ambien more frequently, at higher doses, or for longer than prescribed can increase the risk of dependence, addiction, overdose, or other complications.
Does Ambien Stop Working?
For some people, Ambien stops working as tolerance occurs.[14] This is another reason that Ambien is recommended as a short-term (as short as possible) solution for insomnia.
Controlled substances – alpha order – dea diversion control division. (n.d.-a). Retrieved from https://deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf on 2023. July 2.
Heydari, M., & Isfeedvajani, M. S. (2013, November). Zolpidem dependence, abuse and withdrawal: A case report. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906775/ on 2023, July 2.
GABA receptor – statpearls – NCBI bookshelf. (n.d.-b). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK526124/ on 2023, July 2.
Zolpidem (Oral route). (2024, May 2). Retrieved from https://www.mayoclinic.org/drugs-supplements/zolpidem-oral-route/precautions/drg-20061195 on 2024, June 6.
Zolpidem Monograph for Professionals. (n.d.). Drugs.com. Retrieved from https://www.drugs.com/monograph/zolpidem.html on 2024, June 7.
Zolpidem: MedlinePlus drug information. (n.d.). Retrieved from https://medlineplus.gov/druginfo/meds/a693025.html on 2024, June 6.
Ferguson, S. (2022, October 19). How to Recognize and Manage the Symptoms of Post-Acute Withdrawal Syndrome. Healthline. Retrieved from https://www.healthline.com/health/post-acute-withdrawal-symptoms on 2024, June 6.
Zolpidem monograph for professionals. Drugs.com. (n.d.). Retrieved from https://www.drugs.com/monograph/zolpidem.html on 2023, July 2.
Mattoo, S. K., Gaur, N., & Das, P. P. (2011, November). Zolpidem withdrawal delirium. Indian journal of pharmacology. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229797/ on 2023, July 2.
Mayo Foundation for Medical Education and Research. (2023, April 5). Insomnia treatment: Cognitive behavioral therapy instead of Sleeping Pills. Mayo Clinic. Retrieved from https://www.mayoclinic.org/diseases-conditions/insomnia/in-depth/insomnia-treatment/art-20046677 on 2023, July 2.
What is insomnia? | NHLBI, NIH. (2022, March 24). NHLBI, NIH. Retrieved from https://www.nhlbi.nih.gov/health/insomnia on 2024, June 6.
Awasthi, H., & Vohra, A. (2023). Abrupt withdrawal from Chronic High-Dose Zolpidem use: a case report of resulting delirium. Curēus. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10658757/ on 2024, August 16th.
Zolpidem monograph for professionals. Drugs.com. (n.d.). Retrieved from https://www.drugs.com/monograph/zolpidem.html on 2023, July 2.
Göder R;Treskov V;Burmester J;Aldenhoff JB;Hinze-Selch D; (n.d.). [zolpidem: The risk of tolerance and dependence according to case reports, systematic studies and recent molecularbiological data]. Fortschritte der Neurologie-Psychiatrie. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11753748/ on 2023, July 2.
Additional Resources
Also see these additional resources on withdrawal timelines and treatment: