What Happens When You Mix Oxy and Weed?
Drug Interactions and Health Risks
The use of marijuana, commonly known as weed, has been steadily growing over the past few years as states decriminalized or legalized it. Whether it’s used medicinally or recreationally, marijuana is generally thought of as a safe and natural drug – even a healthy alternative to prescription medications like painkillers.
Unfortunately, mixing painkillers—like oxycodone (oxy), percocet, hydrocodone—and weed can be a dangerous combination.
Key Points
- Weed, or cannabis, contains THC, which stimulates a chemical dopamine response.
- Oxy, or Oxycontin®, is a painkiller for moderate to severe pain that activates a “high.”
- Both substances are considered CNS (central nervous system) depressants, slowing down body functions.
- Taking them together can suppress the central nervous system to dangerous levels, leading to low blood pressure, decreased brain function, extreme sedation, coma, and death.
- Treatment for polydrug abuse includes medical detox, inpatient rehab, therapeutic interventions, group support, and coping skill development.
The Effects of Marijuana
Marijuana contains compounds that affect the body and mind. The psychoactive ingredient is tetrahydrocannabinol (THC), which creates a high by stimulating the part of the brain responsible for pleasure and releasing the “feel-good” chemical dopamine.[1]
For many, the effects of marijuana may include:
- Happiness
- Increased sociability
- Enhanced sensory perception
- Sedation
- Relaxation
- Lightheadedness
These effects of cannabis aren’t consistent in everyone, however. Some people experience heightened anxiety or paranoia with cannabis use, even medical cannabis, and it can have negative impacts on memory, concentration, thought processes, the perception of time and senses, and coordination.
It also has adverse physical effects, including:[2]
- Excessive coughing
- Increased appetite
- Bloodshot eyes
- Low blood pressure
Increased heart rate
With long-term use, marijuana use can cause:
- Anxiety
- Depression
- Psychotic issues
- Diminished intelligence
- Reduced athletic ability
- Suicidal ideation or actions
- In young users, developmental delays
- Addiction
Other Side Effects
They also create effects like:
- Confusion
- Drowsiness
- Nausea
- Constipation
- Euphoria
- Slowed breathing
When breathing is slowed significantly, it can cause hypoxia, a condition in which too little oxygen reaches the brain. There are short- and long-term risks with hypoxia, including permanent brain damage, coma, or death.
Opioids carry a high risk of overdose and death. According to the Centers for Disease Control and Prevention, there were 107,622 drug overdose deaths involving opioids in 2021, which is an increase of 15% since 2020.[4]
The Dangers of Mixing Opioids and Marijuana
With the risks of overdose from opioids, marijuana has been suggested as a way to supplement opioid painkillers for analgesic effects (pain-relieving effects) or transition off of opioid painkillers for chronic pain. In one study, people who combined oxycodone and marijuana experienced an enhanced pain threshold and tolerance compared to oxycodone on its own.[5]
The goal of combining oxycodone and weed or hydrocodone and weed is to reduce the doses of opioid painkillers while getting the same pain relief, which could potentially reduce the risk of prescription opioid addiction and opioid overdoses.
Unfortunately, marijuana and opioids share depressant effects. Combining the two can suppress the central nervous system to dangerous levels, leading to low blood pressure, decreased brain function, extreme sedation, coma, and death.
Marijuana and painkillers may be combined for recreational use as well. According to one study, seven out of 10 teens who take prescription opioids for recreational use combine them with other drugs or alcohol, including marijuana.
Using marijuana isn’t necessarily effective in reducing opioid misuse, either. According to data from the National Epidemiologic Survey on Alcohol and Related Conditions, marijuana users are more than two-and-a-half times more likely to misuse prescription opioids and develop prescription opioid use disorder (OUD) than nonusers.[7]
Treatment for Polydrug Abuse
The use or abuse of two or more drugs simultaneously is called polydrug abuse, polysubstance abuse, or polysubstance use disorder.[8]
Though it’s common for people to combine drugs, such as taking prescription painkillers with marijuana or having a glass of wine, these are forms of polydrug abuse. Unsurprisingly, using more than one substance at once increases the risk of abuse and dependency.
If you or a loved one suffers from the effects of polysubstance abuse involving opioid painkillers and marijuana – or any other substance abuse – treatment can help.
Because of the highly addictive nature of opioid painkillers and the potentially life-threatening withdrawal, medical detox is often the first step to recovery. During medical detox, you can safely clear your system of opioids while medical staff monitors your condition and manages your symptoms with medication to keep you safe and comfortable.
After detox, you can undergo inpatient substance use disorder treatment and focus solely on your recovery. Generally, individual and group therapies are used with behavioral therapies like cognitive behavioral therapy (CBT), which helps to modify substance use expectations and behaviors while managing triggers and stress.
Other treatments may be included, such as medication-assisted therapy (MAT), multidimensional family therapy, and couple’s therapy, depending on the individual circumstances.
Frequently Asked Questions
Is It Good to Combine Percocet and Weed?
While combining Percocet and weed can have benefits, it’s important to only combine these drugs under the supervision of a healthcare professional. These drugs are both depressants and can be a potentially fatal combination, leading to symptoms like an extreme drop in blood pressure, hypoxia, seizures, coma, and death.
Can You Mix Hydrocodone and THC?
THC, the main cannabinoid in marijuana, can cause adverse effects when mixed with other drugs, including hydrocodone and other opioids.[9] Combining the two depresses the central nervous system, leading to drowsiness, loss of coordination, hypoxia, coma, and death.
Can You Eat Edibles While Taking Medication?
Depending on the medication, mixing it with edible cannabis products can have dangerous interactions.[10] Aside from opioid painkillers, blood thinners, antidepressants, and anticholinergics, such as for Parkinson’s disease. Sympathomimetics, such as nasal decongestants, appetite suppressants, and some ADHD medications, are also contraindicated with marijuana.
What Drugs Shouldn’t Be Taken with CBD?
Cannabidiol (CBD), another cannabinoid in marijuana, is different from THC. It’s touted for its therapeutic effects, not psychoactive effects, but it can still have dangerous interactions with other drugs.[11] Avoid mixing CBD with anticonvulsants, barbiturates or other sedative drugs, and narcotics like opioid painkillers.
U.S. Department of Health and Human Services. (2021, April 19). What are marijuana’s effects? National Institutes of Health. Retrieved from https://nida.nih.gov/publications/research-reports/marijuana/what-are-marijuana-effects on 2023, June 21.
U.S. Department of Health and Human Services. (2021, April 19). What are marijuana’s effects? National Institutes of Health. Retrieved from https://nida.nih.gov/publications/research-reports/marijuana/what-are-marijuana-effects on 2023, June 21.
U.S. Department of Health and Human Services. (2023, May 25). Prescription opioids Drugfacts. National Institutes of Health. Retrieved from https://nida.nih.gov/publications/drugfacts/prescription-opioids on 2023, June 21.
Centers for Disease Control and Prevention. (2022, May 11). U.S. overdose deaths in 2021 increased half as much as in 2020 – but are still up 15%. Centers for Disease Control and Prevention. Retrieved from https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2022/202205.htm on 2023, June 21.
Cooper, Z. D., Bedi, G., Ramesh, D., Balter, R., Comer, S. D., & Haney, M. (2018, February 5). Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability. Nature News. Retrieved from https://www.nature.com/articles/s41386-018-0011-2 on 2023, June 21.
Rogers AH;Bakhshaie J;Buckner JD;Orr MF;Paulus DJ;Ditre JW;Zvolensky MJ; (n.d.). Opioid and cannabis co-use among adults with chronic pain: Relations to substance misuse, mental health, and Pain experience. Journal of addiction medicine. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30557213/ on 2023, June 21.
McCabe, S. E., West, B. T., Teter, C. J., & Boyd, C. J. (2012, November 1). Co-ingestion of prescription opioids and other drugs among high school seniors: Results from a national study. Drug and alcohol dependence. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478441/ on 2023, June 21.
Centers for Disease Control and Prevention. (2022a, February 23). Polysubstance use facts. Centers for Disease Control and Prevention. Retrieved from https://www.cdc.gov/stopoverdose/polysubstance-use/index.html on 2023, June 21.
Antoniou, T., Bodkin, J., & Ho, J. M.-W. (2020, March 2). Drug interactions with cannabinoids. CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055953/ on 2023, June 21.
Antoniou, T., Bodkin, J., & Ho, J. M.-W. (2020, March 2). Drug interactions with cannabinoids. CMAJ : Canadian Medical Association journal = journal de l’Association medicale canadienne. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055953/ on 2023, June 21.
Balachandran, P., Elsohly, M., & Hill, K. P. (2021, July). Cannabidiol interactions with medications, illicit substances, and Alcohol: A Comprehensive Review. Journal of general internal medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298645/#on 2023, June 21.
